To make skype run on a usb flash drive or some other portable device follow the following:
First...Download the NEWEST version of Skype (Older versions won't work) and install it on any computer as normal. Find the Skype.exe from where it was installed.
(Usually C:\Program Files\Skype\Phone\Skype.exe ) Copy the Skype.exe file to any directory on your USB Drive In that new directory create a directory called "data" Now create a file (with notepad) called "skype.bat" Edit the "skype.bat" file and place the following line there:
skype.exe /datapath:"Data" /removable